CROSS LINKED CHITOSAN IN SITU GEL OF SATRANIDAZOLE FOR INTRA PERIODONTAL DRUG DELIVERY
نویسندگان
چکیده
منابع مشابه
Cross Linked Chitosan in Situ Gel of Satranidazole for Intra Periodontal Drug Delivery
This paper introduces a novel type of injectable temperature-sensitive chitosan polymer based in situ gel for the local delivery of Satranidazole into the infected periodontal pocket. The thermo gelling polymer, chitosan with different concentrations has been used for formulation of in situ gel of Satranidazole with 10 % propylene glycol as plasticizer and was allowed to cross linked with 1 % s...
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Objective: The goal in using a local nonsurgical controlled intrapocket device for the delivery of an antimicrobial agent is the achievement and maintenance of therapeutic drug concentration for the desired period of time. Methods: The study was conducted to fabricate a bio erodible delivery system for Satranidazole, dispersed in two different polymers, natural Chitosan and semi synthetic HPMC ...
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This study proposed a drug delivery system based on a series of formulations with chitosan gels, designed for local, intra-pocket treatment of periodontal disease, containing two drugs (an antibiotic and a chimiotherapeutic-antimicrobian agent: tetracycline hydrochloride (T) and metronidazole benzoate (M), respectively. The formulations varied from the chitosan concentration (3-4%), and the dru...
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Recently, specific attention has been paid to aptamers, short DNA or RNA, as a tool for cancer diagnosis and therapy. In the present study MCS nanogels were prepared by Myristate: chitosan at 1:9 ratio and were characterized by several techniques. A selected ssDNA aptamer(Apt) capable of detecting LNCaP cells was linked to Myristilated chitosan nanogels (Apt-MCS) by glutaraldehyde and loaded wi...
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Recently, specific attention has been paid to aptamers, short DNA or RNA, as a tool for cancer diagnosis and therapy. In the present study MCS nanogels were prepared by Myristate: chitosan at 1:9 ratio and were characterized by several techniques. A selected ssDNA aptamer(Apt) capable of detecting LNCaP cells was linked to Myristilated chitosan nanogels (Apt-MCS) by glutaraldehyde and loaded wi...
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ژورنال
عنوان ژورنال: INTERNATIONAL RESEARCH JOURNAL OF PHARMACY
سال: 2014
ISSN: 2230-8407
DOI: 10.7897/2230-8407.050580